THE MOST COMPREHENSIVE OVARIAN REJUVENATION TREATMENT

Revitalize treatment is a procedure developed by Equipo Juana Crespo that combines different techniques previously used separately and that, together and applied in individualised fashion, improve the functionality of the ovaries and uterus, achieving spectacular results.

Revitalize enhances results for all treatments, both at ovarian level and for endometrial preparation. However, it really shines in patients with poor reproductive prognosis.

• ≥ 35 years old

• RFA < 5

• AMH < 1.2 ng/ml

• < 4 Oocytes retrieved in previous stimulations

• Little or no endometrial growth

RFA: Recuento folículos antrales.
AMH: Antimülleriana

The mobilization of bone marrow stem cells and our own innovative technique of micropunctures (microinjections) of platelet-rich plasma means we can improve embryo quality and optimal endometrial thickening, which results in effective and proven improvement in the chances of a successful full-term pregnancy for women with a very poor reproductive prognosis.

The treatment involves a combination of several techniques.

Revitalize is a comprehensive treatment compared to other types of ovarian rejuvenation. Published studies have shown that PRGF instillation or microinjection alone has no significant efficacy in successful full-term pregnancies.  

However, successful full-term pregnancies from Revitalize treatments were 44% higher than for other ovarian rejuvenation procedures, because they incorporate the surgical PRGF administration strategy and highly personalised endometrial stimulation and/or preparation.

A woman’s ovarian reserve is made up of primordial follicles called dormant follicles found in the ovary from birth. Each month, the ovary activates about 1,000 primordial follicles in a process lasting several months until they become a more complete structure, namely the antral follicles.

The antral follicles are visible by ultrasound at the beginning of the cycle and can be stimulated hormonally; either naturally by the woman’s own body, or using drugs in an assisted reproduction treatment.

The Equipo Juana Crespo has managed to increase the pregnancy success rate in women with very poor reproductive prognosis with their own eggs and whose only option was egg donation treatment.

Patients with useful embryos

Gestation rate

Successful full-term pregnancy

EJC RESULTS  – Average age 41 years old

PUBLICATION A –  Jun/20 / Average age 40.3 years old

PUBLICATION B –  Mar/22 /No age specified

Additionally, 7% of patients who underwent the Revitalize Ovary procedure achieved natural pregnancy.

This is an ambulatory technique involving:

This procedure is indicated only in patients with surgical indication for other reasons.

It involves a minimally invasive procedure performed at our clinic.

This is a comprehensive technique that revitalises the endometrium, especially the cells of the myometrial- endometrial interface, i.e., the subendometrium.

Our experience in treating endometrium for reproductive purposes has allowed us to develop our own technology for which, via different tests, we select the specific area of the uterus and map the area where the PRGF micropunctures will be performed, to maximise results.

The endometrium is the innermost mucous layer of the uterus whose main function is to facilitate embryo implantation. The endometrium changes morphologically and functionally throughout the menstrual cycle due to the effect of hormones (estrogens and progesterone) and proper vascularisation. 

Hostile uterus is characterised by poorly growing, heterogeneous endometrial lines or subendometrial adenomyosis on ultrasound. Revitalize Endometrium, through the stimulation of stem cells and the work of PRP administered by puncture, improves vascularisation and the action of growth factors so that the subendometrium stem cells function better.

The outcome is a more functional endometrium, a decrease in inflammatory lesions and consequently an improvement in the embryo implantation process, both in the adhesion and invasion of the embryo, thus achieving better results for the newborn at home

For endometrial revitalization, there are two hysteroscopy options that Juana Crespo Team specialists prescribe based on the original pathology, and these involve:

The endometrial regeneration technique is fairly new but has achieved excellent results in patients with no or very little endometrial growth, reaching an optimal endometrial line for embryo implantation.

The endometrial regeneration technique is fairly new but has achieved excellent results in patients with no or very little endometrial growth, reaching an optimal endometrial line for embryo implantation.